Back to Blog
Stranded by J.C. Valentine6/2/2023 ![]() ![]() Comparative analysis indicates recent intragenomic duplication of DGR targets as paralogs, but also apparent intergenomic exchange of DGR components. This class of retroelements diversifies target proteins with unique domain architectures: modular ligand-binding domains often paired with a second domain that is linked to signal response or regulation. Members of 31 cyanobacterial genera encode at least one DGR, and together, their retroelements form a monophyletic clade of closely-related reverse transcriptases. However, these elements may be critical in driving variation for proteins involved in other core cellular processes. ![]() ![]() Past research has shown DGRs to mainly diversify proteins involved in cell-cell attachment or viral-host attachment within viral, bacterial, and archaeal lineages. Some cyanobacterial genomes have been noted to encode diversity-generating retroelements (DGRs), which promote protein hypervariation through localized retrohoming and codon rewriting in target genes. Cyanobacteria maintain extensive repertoires of regulatory genes that are vital for adaptation to environmental stress. ![]()
0 Comments
Read More
Leave a Reply. |